Cynatroside B <sub>2</sub> , a new anti-inflammatory C <sub>21</sub> steroid from the roots and rhizomes of <i>Vincetoxicum atratum</i>
A series of C<sub>21</sub> steroidal glycosides were isolated from the roots and rhizomes of <i>Vincetoxicum atratum</i> (Bunge) C. Morren et Decne., including a new compound, cynatroside B<sub>2</sub> (<b>1</b>), and seven known compounds (<b>2</b>-<b>8</b>). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound <b>1</b> displayed a significant inhibitory effect on NO, TNF-<i>α</i> and IL-1<i>β</i>.
Authors
- Chongning Lv
- Jing-Yu Zhang
- Yang Yu (ORCID: https://orcid.org/0000-0002-1441-914X)
- Yinuo Shi
- Jincai Lu (ORCID: https://orcid.org/0000-0002-7331-1251)
- Sheng Dong (ORCID: https://orcid.org/0000-0001-9302-4893)
- Chen Ji
- Jiu-Zhi Yuan
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1080/10286020.2024.2446302
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program