A Novel Topical Approach Using Carica papaya and Cellulose Sulfate for STIs Management: A Promising Prevention and Treatment for Sexually Transmitted Infections

Objective: This study explores the efficacy of a novel topical formulation containing Carica papaya extract and cellulose sulfate as a potential prevention and treatment for sexually transmitted infections (STIs). The aim is to evaluate the antimicrobial properties of this combination and its safety for topical use in the prevention and treatment of common STIs. Materials and Methods:A topical formulation was prepared using Carica papaya extract and cellulose sulfate, chosen for their antimicrobial and protective barrier properties. The formulation was tested invitro against common STI pathogens, including Neisseria gonorrhoeae, Chlamydia trachomatis, and Herpes simplex virus (HSV). Cytotoxicity assays were performed using human epithelial cells to assess the safety of the formulation. In addition, animal models were used to test the efficacy of the formulation in preventing infection. Results and Discussion: The in vitro results demonstrated that the combination of Carica papaya and cellulose sulfate effectively inhibited the growth of bacterial and viral STI pathogens. The formulation showed a significant reduction in infection rates in the animal models, particularly for Chlamydia trachomatis and HSV. Cytotoxicity assays revealed no significant adverse effects on human epithelial cells, indicating the safety of the topical application. The synergistic effects of the antimicrobial properties of Carica papaya and the protective barrier formed by cellulose sulfate suggest that this formulation could serve as an effective, non-invasive treatment option for STIs. Conclusion: The study demonstrates the potential of a topical formulation containing Carica papaya and cellulose sulfate for STI management. It offers a promising alternative for the prevention and treatment of STIs, with minimal cytotoxic effects and broad-spectrum antimicrobial activity.