Sonogenetics is a novel antiarrhythmic mechanism

Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic mechanism proposed here focuses ultrasound on a cardiac tissue, controls endogenous stretch-activated Piezo1 ion channels on the focal region's cardiomyocyte sarcolemma, and restores normal heart rhythm. In contrast to anchoring the implanted ICD lead at a fixed position in the myocardium, the size and position of the ultrasound focal region can be selected dynamically by adjusting the signals of every piezoelectric chip on the ultrasonic phased array, and it allows novel and efficient defibrillations. Based on the developed interdisciplinary electro-mechanical model of sonogenetic treatment, our analysis shows that the proposed ultrasound intensity and frequency will be safe and painless for humans and well below the limits established by the U.S. Food and Drug Administration.

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Publication Details

Journal
Chaos An Interdisciplinary Journal of Nonlinear Science
Published
2025-01-01
DOI
https://doi.org/10.1063/5.0224817
Citations
1
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
1.39

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article

Sonogenetics is a novel antiarrhythmic mechanism

V. S. Zykov, Yang Li, Xingang Wang, Eberhard Bodenschatz et al.
1 citations
Chaos An Interdisciplinary Journal of Nonlinear Science
Cardiac electrophysiology and arrhythmias
1.39
article

Sonogenetics is a novel antiarrhythmic mechanism

V. S. Zykov, Yang Li, Xingang Wang, Eberhard Bodenschatz, Xiang Gao, Yong Wang, Jianzhong Guo
article en
1 citations

Abstract

Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic mechanism proposed here focuses ultrasound on a cardiac tissue, controls endogenous stretch-activated Piezo1 ion channels on the focal region's cardiomyocyte sarcolemma, and restores normal heart rhythm. In contrast to anchoring the implanted ICD lead at a fixed position in the myocardium, the size and position of the ultrasound focal region can be selected dynamically by adjusting the signals of every piezoelectric chip on the ultrasonic phased array, and it allows novel and efficient defibrillations. Based on the developed interdisciplinary electro-mechanical model of sonogenetic treatment, our analysis shows that the proposed ultrasound intensity and frequency will be safe and painless for humans and well below the limits established by the U.S. Food and Drug Administration.

Chaos An Interdisciplinary Journal of Nonlinear ScienceVol. 35(1)
Beijing University of Posts and Telecommunications (CN), Cornell University (US), Max Planck Institute for Dynamics and Self-Organization (DE), German Centre for Cardiovascular Research (DE), University of Göttingen (DE), Shaanxi Normal University (CN)
Deutsches Zentrum für Herz-Kreislaufforschung, National Natural Science Foundation of China, Bundesministerium für Bildung und Forschung, Natural Science Basic Research Program of Shaanxi Province
Openalex Percentile: Top 24%
Cardiac electrophysiology and arrhythmias
1.39
DOIOpen Access PDFOpenAlex
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