Activation of δ‐opioid receptors blocks allodynia in a model of headache induced by PACAP
We developed a translationally significant model of PACAP-induced headache, which was mechanistically distinct from CGRP. Activation of δ-receptors blocked PACAP- and CGRP-induced allodynia, and δ-receptors were highly co-expressed with the PACAP-ergic system. Future studies will examine the functional relationship between δ-receptors and PAC1.
Authors
- Isaac Dripps
- Timothy Halbesma
- Sarah Asif (ORCID: https://orcid.org/0000-0001-7953-8206)
- Wiktor Witkowski (ORCID: https://orcid.org/0000-0002-0296-5055)
- Elizaveta Mangutov
- Kendra Siegersma (ORCID: https://orcid.org/0000-0002-6578-5561)
- Amynah Pradhan (ORCID: https://orcid.org/0000-0001-9691-2976)
- Rebecca Bocian
- Yanping Zhang (ORCID: https://orcid.org/0009-0008-3171-6614)
Institutions
- Washington University in St. Louis (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1111/bph.17424
- Citations
- 9
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke