Evaluating the differential effects of dopamine agonists and clonazepam on large muscle group movements in restless legs syndrome
DA effectively reduced PLMS but did not significantly impact LMM, suggesting that LMM may involve different neurophysiological mechanisms. The potential FNE observed in the placebo group underscores the need for careful consideration of adaptation effects in sleep studies. Future research should explore alternative or adjunctive therapies targeting LMM and residual sleep disturbances in RLS.
Authors
- Monica Puligheddu (ORCID: https://orcid.org/0000-0002-6837-6608)
- Alessandra Castelnuovo (ORCID: https://orcid.org/0000-0001-7037-0208)
- Giuseppe Lanza (ORCID: https://orcid.org/0000-0002-5659-662X)
- Raffaele Ferri (ORCID: https://orcid.org/0000-0001-6937-3065)
- Maria P. Mogavero (ORCID: https://orcid.org/0000-0001-6662-2281)
- Oliviero Bruni (ORCID: https://orcid.org/0000-0003-2207-1398)
- Sara Marelli (ORCID: https://orcid.org/0000-0003-0074-5371)
- Patrizia Congiu (ORCID: https://orcid.org/0000-0002-7680-8722)
- Luigi Ferini‐Strambi (ORCID: https://orcid.org/0000-0003-2867-5424)
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Cagliari (IT)
- University of Catania (IT)
- Oasi Maria SS (IT)
- Surgical Specialties (Canada) (CA)
- Mylan (South Africa) (ZA)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- SLEEP
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1093/sleep/zsae310
- Citations
- 5
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 6.77