The Role of Curcumin on Rhinovirus (HRV14) Protein Inhibition by Targeting Host and Viral Proteins

This in-silico analysis aims to explain curcumin's effects and how (HRV14) protein may cure the common cold fever. Human rhinoviruses predominantly cause the common cold and are responsible for the manifestation of maximum upper respiratory tract viral infections. Human rhinovirus belongs to the Picornaviridae family and is part of the genus Enterovirus. More than 150 HRV variants are categorized as species A, B, and C. Exacerbations of chronic obstructive pulmonary disease, asthma, and cystic fibrosis have also been linked to rhinoviruses. In this research work, turmeric is selected as the plant source, and curcumin is a phytochemical constituent selected for the in-silico analysis against the common cold. Humans have relied on plants for medicinal purposes since the dawn of time. Curcuma longa L. is the scientific name for turmeric, which belongs to the family Zingiberaceae of plants. It is grown in almost every country on this planet, with the majority of production taking place in Asia, Europe, North America, and the United States. It is a common spice and aromatic crop, and dried seeds are used in various foods, medicines, and beverage formulations. It has many therapeutic properties, such as anti-carcinogenic, anti-diabetic, hypocholesterolemic, anti-microbial, and antioxidant activities. In this research, an in silico analysis of curcumin against rhinovirus capsid protein HRV14 was performed using Auto Dock Vina software. The ligands were successfully bound to the active site of the rhinovirus capsid protein HRV14 and showed no toxicity and good drug scores. So, the study signifies that this ligand may be tried clinically and may act as a potential drug applicant against the common cold.