Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes

In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.