Antimicrobial and Antifungal Evaluation of Some Novel Thiazolidin-4-one Scaffold Bearing Compounds

A series of novel hybrid Thiazolidinone derivatives 4, 5 (a-e) were designed and synthesized by combining more than one bioactive scaffold. All synthesized compounds were tested for their in vitro antimicrobial activity against gram-positive and gram-negative bacteria, including strains such as S. aureus (MTCC-737), P. aeruginosa ((MTCC-424), and Salmonella typhi (MTCC531). The antifungal activity was also screened for fungal strain C. albicans (MTCC-3378) against the reference drug Ciprofloxacin. Compounds 1, 3, 8, and 9 were proved to show the highest activity against all bacterial and fungal strains at 500 μg/mL with Zone of Inhibition 15.22±0.08 - 19.93±0.09. The substitution with electron-donating groups on the phenyl ring decreases the antimicrobial activity, whereas the presence of the nitro group shows no antifungal activity. Chloro-substituted compounds 3 and 8 exhibited significant inhibition.