Iron Chelation Prevents Age‐Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging
In summary, our research findings indicate that deferiprone reduced age-related sarcopenia in the muscles of Klotho<sup>-/-</sup> mice. Our finding suggests chelation of excess iron could be an effective therapy to counter sarcopenia. However, additional studies are needed to evaluate and determine the efficacy in humans.
Authors
- Sharda P. Singh (ORCID: https://orcid.org/0000-0003-4361-4558)
- Oleg Karaduta (ORCID: https://orcid.org/0000-0003-3873-052X)
- Sudhir V. Shah (ORCID: https://orcid.org/0009-0006-2403-8136)
- Sundararaman Swaminathan
- Judit Megyesi
- Chhanda Bose (ORCID: https://orcid.org/0000-0002-2121-4214)
Institutions
- Central Arkansas Veterans Healthcare System (US)
- University of Arkansas for Medical Sciences (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1002/jcsm.13678
- Citations
- 9
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- U.S. Department of Veterans Affairs