Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice
Chronic gadolinium retention alters gene expression in the mouse central nervous system. Significant neuroinflammatory pathway changes were observed after linear gadodiamide exposure. MRI showed increased signal intensity in deep cerebellar nuclei after gadodiamide injection.
Authors
- Yuxia Tang (ORCID: https://orcid.org/0000-0002-0040-6145)
- Chuanbing Wang (ORCID: https://orcid.org/0000-0001-6252-5580)
- Jiajia Tang (ORCID: https://orcid.org/0000-0001-6036-6133)
- Shouju Wang (ORCID: https://orcid.org/0000-0001-9213-6818)
- Siqi Wang (ORCID: https://orcid.org/0000-0002-1491-2962)
- Jie Zhang (ORCID: https://orcid.org/0000-0003-2493-5209)
- Feiyun Wu
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s41747-024-00546-x
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Pharmaceutical University
- Nanjing Medical University