Exploring the medication pattern of traditional Chinese medicine for treating qi stagnation and blood stasis type chronic pelvic inflammation based on data mining technology

OBJECTIVE: Data mining of Chinese herbal prescriptions for the treatment of chronic pelvic inflammatory disease of the qi stagnation and blood stasis type yielded the pattern of medication, providing reference for clinical application. METHODS: Literature on the treatment of qi stagnation and blood stasis-type chronic pelvic inflammatory disease by traditional Chinese medicine was collected from China National Knowledge Infrastructure, Wanfang Data, China Biology Medicine disc, and China Science and Technology Journal Database since the establishment of the database and screened for those that met the criteria, to establish a database on the treatment of qi stagnation and blood stasis-type chronic pelvic inflammatory disease by traditional Chinese medicine. The frequency, efficacy, sex and flavour attribution of Chinese medicines were analyzed using Microsoft Office Excel 2019 and Origin 2022 software, and the association rule analysis and cluster analysis of high-frequency medicines were performed using IBM SPSS Modeler 18.0 and IBM SPSS Statistics 27. Results: A total of 112 articles were included in the literature, involving 144 Chinese herbal tastes of traditional Chinese medicines, with a total frequency of use of 1412 times, among which the medicines used ⩾ 35 times were Angelica sinensis, Cyperus rotundus, Fumaric, Red peony, Ligusticum wallichii, Licorice, Peach kernel, Salvia miltiorrhiza, Fructus Aurantii, Safflower, Radix bupleuri, and Peony bark. The drug tastes were mainly warm and bitter, the attributive meridians were mainly liver, spleen, and stomach, and the efficacy was mainly to activate blood circulation and remove blood stasis, regulate qi, tonify the deficiency, and clear heat. The results of association rule analysis showed that the core drug pairs were 'Ligusticum wallichii - Angelica sinensis', 'Licorice - Angelica sinensis', etc. and the commonly used combinations were 'Ligusticum wallichii, Angelica sinensis -Red peony', 'Licorice, Angelica sinensis - Red peony', etc. The HF drugs were clustered into 7 classes by systematic cluster analysis. CONCLUSION: In this paper, the preliminary summary of Chinese medicine treatment of qi stagnation and blood stasis type of chronic pelvic inflammatory disease of the law of medication, treatment of this disease is mostly from the theory of the liver and spleen, to activate blood and eliminate blood stasis, regulate qi to stop pain as the main rule of treatment, the use of medication is mostly warm and cold, to activate blood and eliminate blood stasis medicines are mainly focused on regulating qi to activate blood, dredge the liver to resolve depression.