Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
These findings emphasize the importance of antigen localization in tailoring immune responses and suggest that extracellular antigens are more effective for inducing humoral responses, whereas cytosolic antigen accumulation enhances MHC-1 peptide presentation. Future studies will determine if these in vitro and immunogenicity findings translate to in vivo efficacy. Altogether, mRNA vaccines offer numerous possibilities in the development of multivalent vaccines with single or multiple antigens.
Authors
- Andrey Carlos do Sacramento de Oliveira (ORCID: https://orcid.org/0000-0001-6637-2606)
- María Elena Bottazzi (ORCID: https://orcid.org/0000-0002-8429-0476)
- Rakesh Adhikari (ORCID: https://orcid.org/0000-0003-0829-232X)
- Leroy Versteeg (ORCID: https://orcid.org/0000-0001-5250-5746)
- Neima Briggs (ORCID: https://orcid.org/0000-0002-5583-7057)
- JeAnna R. Redd (ORCID: https://orcid.org/0000-0001-6012-728X)
- Jeroen Pollet (ORCID: https://orcid.org/0000-0003-1420-4015)
- Peter J. Hotez (ORCID: https://orcid.org/0000-0001-8770-1042)
- María José Villar (ORCID: https://orcid.org/0000-0002-2939-1928)
Institutions
- Baylor University (US)
- Baylor College of Medicine (US)
- Yale University (US)
- Texas Children's Hospital (US)
- Rice University (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1371/journal.pntd.0012809
- Citations
- 5
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 10.24
Funders
- Texas Children's Hospital
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Center for Research Resources