Evaluating the Impact of Variants on Translation Initiation Sites for Accurate Identification of Functional Open Reading Frames (ORFs)

VarTIS is a computational tool that utilizes multi-branch Convolutional Neural Networks (CNNs) to analyze genetic variants near Translation Initiation Sites (TIS), assessing their impact on translation efficiency. By comparing variant densities in protein-coding regions with adjacent untranslated regions, VarTIS helps identify potential disruptions in the proper identification of functional Open Reading Frames (ORFs).