Possibilities of implementation of personalized medicine using the genetic features of the vitamin D receptor

The article investigated three polymorphic variants of the VDR vitamin D receptor gene (rs1544410, rs4516035 and TaqI (rs731236) in 347 people from different regions of Ukraine, aged from 1 to 69 years. The results showed variability in the frequencies of alleles and genotypes of VDR polymorphic variants. The objective: based on the data of genetic studies, to evaluate the variation of genotypes of VDR – the vitamin D receptor gene in the Ukrainian population.Materials and methods. VDR genotype was determined using the polymerase chain reaction (PCR) method and high-throughput exome sequencing (next generation sequencing – NGS) of a new generation on the Illumina’s HiSeq device (made in the USA). Buccal epithelium and saliva served as material for genotyping. The obtained digital data were processed statistically in the R environment. Results. It was established , that carriers of certain genetic variants of the VDR gene have an increased risk of vitamin D deficiency, which is extremely important for improving personalized prevention of vitamin D deficiency.Conclusions. Identification of carriers of mutations in the VDR gene will improve the quality of diagnostics, which will make it possible to provide personalized prevention of vitamin D insufficiency and deficiency and pathologies associated with this gene, as well as to stratify the population by risk groups at the preclinical stage.