Vaccine Specifically for Immunocompromised Individuals against Superbugs
Immunocompromised populations, including cancer patients, elderly individuals, and those with chronic diseases, are the primary targets of superbugs. Traditional vaccines are less effective due to insufficient or impaired immune cells. Inspired by the "vanguard" effect of neutrophils (NE) during natural infection, this project leverages the ability of NE to initiate the NETosis program to recruit monocytes and DC cells, designing vaccines that can rapidly recruit immune cells and enhance the immune response. The PLGA microsphere vaccine platform (MSV) with a high level of safety contains whole-bacterial antigens both internally and externally, providing initial and booster effects through programmed distribution and release of antigens after a single injection. Experimental data indicate that immunizing mice with a mixture of MSV and NE induces the formation of spontaneous gel-like neutrophil extracellular traps (NETs) at the inoculation site. These NETs recruit immune cells and prevent the diffusion of vaccine components, thereby reducing damage from bacterial toxins and enhancing vaccine biosafety. This strategy shows excellent efficacy against MRSA-induced infections in not only healthy but also immunocompromised mice.
Authors
- Xin‐Dong Jiang (ORCID: https://orcid.org/0000-0002-9780-1124)
- Jian You (ORCID: https://orcid.org/0000-0002-7114-6299)
- Qingpo Li (ORCID: https://orcid.org/0000-0003-3893-3175)
- Junlei Zhang (ORCID: https://orcid.org/0000-0001-5671-6081)
- Yingying Shi (ORCID: https://orcid.org/0000-0002-2712-2126)
- Shuhan Ji (ORCID: https://orcid.org/0000-0002-3992-656X)
- Fuchun Yang
- Yitao Zhang
- Litong Wang (ORCID: https://orcid.org/0000-0001-8368-7626)
- Sijie Wang (ORCID: https://orcid.org/0009-0007-5688-1993)
- Zhenyu Luo (ORCID: https://orcid.org/0000-0003-3686-9595)
- Shenyu Wang (ORCID: https://orcid.org/0000-0002-0173-1644)
- Lihua Luo (ORCID: https://orcid.org/0000-0002-2129-4226)
- Jiaxin Huang (ORCID: https://orcid.org/0000-0001-7232-9313)
- Zhaolei Jin
- Miaoyuan Shi
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1021/acsnano.4c12203
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
- National Postdoctoral Program for Innovative Talents
- National Key Research and Development Program of China
- Science and Technology Department of Zhejiang Province