Serum levels of several cytokines in undifferentiated connective tissue dysplasia in adolescent girls

The problem of connective tissue dysplasia is caused by the widespread spread among the population, the progressive nature of the disease, the involvement of various organs and systems in the lesion, a sufficiently high disability of patients and a decrease in working capacity. The aim – of the study was to study the serum content of certain pro- and anti-inflammatory cytokines in adolescent girls with undifferentiated connective tissue dysplasia and menstrual cycle disorders. 245 adolescent girls aged 11 to 17 years were examined (14.0 ± 0.15 years). Among them, 176 patients assigned to the main group were characterized by menstrual irregularities and the presence of UCTD. The control group was represented by conditionally healthy females of the same age in the number of 69 people. The content of interleukins - IL-1β (1. -4, -6, -10, -17A, and tumor necrosis factor-а were determined in blood serum samples using commercial enzyme immunoassay systems. It was found that in UCTD with menstrual cycle disorders in adolescent girls, the concentration of proinflammatory IL-6 in the blood serum increased ( p = 0.002), at the same time, no changes in the content of IL-1β (IL-4, IL-10, IL-17A and tumor necrosis factor- ɑ ( p > 0.05) were detected. The obtained data characterize the features of cytokine status, in menstrual disorders against the background of undifferentiated connective tissue dysplasia in adolescent girls and can be used to develop effective individualized schemes of diagnostic and therapeutic, and preventive measures.