Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer
Taken together, our findings suggested that exosomal ITGA6 and ITGB4 displayed organotropism to the lung and upregulated proliferation and tubulogenic capacities, which might help reduce lung metastasis from CRC. These findings provided new insights into the mechanisms of CRC metastasis and provided novel potential therapeutic targets.
Authors
- Weizhong Tang (ORCID: https://orcid.org/0000-0003-0877-8557)
- Jiahao Huang (ORCID: https://orcid.org/0000-0002-9342-2418)
- Guanhua Qiu (ORCID: https://orcid.org/0000-0003-4994-7011)
- Fengyun Cong
- Changtao Wu
- Tao Luo (ORCID: https://orcid.org/0000-0002-4861-3397)
- Huage Zhong (ORCID: https://orcid.org/0000-0002-5217-4606)
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.4103/jcrt.jcrt_230_24
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.94