Ethyl Acetate Extract of Cichorium glandulosum Activates the P21/Nrf2/HO-1 Pathway to Alleviate Oxidative Stress in a Mouse Model of Alcoholic Liver Disease
CGE mitigates oxidative stress and liver injury by activating the P21/Nrf2/HO-1 pathway and regulating antioxidant genes. Its hepatoprotective effects and multi-target mechanisms highlight CGE's potential as a promising therapeutic candidate for ALD treatment.
Authors
- Shuwen Qi
- Junlin Yan
- Chunzi Zhang
- Yewei Zhong
- Juan Zhang (ORCID: https://orcid.org/0000-0003-2349-1714)
- Wenhui Hou
- Xiaoli Ma (ORCID: https://orcid.org/0000-0003-3127-0364)
- Xiaoyan Ma
- Tuxia Pang
Institutions
- Xinjiang Medical University (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3390/metabo15010041
- Citations
- 6
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Science and Technology Department of Xinjiang Uygur Autonomous Region
- Xinjiang Medical University