Novel functional eQTL-SNPs associated with susceptibility to occupational pulmonary fibrosis: A multi-stage study
The rs1620530 and rs2070063 may affect the silicosis susceptibility by regulating the expression of the MAD1L1 and SERTAD2, respectively. Further biological experiments are warranted to elucidate the underlying biological mechanisms between these two SNPs and the increased susceptibility to silicosis.
Authors
- Rui Zhao (ORCID: https://orcid.org/0000-0001-8794-8299)
- Wendi Zhang
- Minjie Chu (ORCID: https://orcid.org/0000-0002-7533-9119)
- Zhenyu Li (ORCID: https://orcid.org/0000-0002-6719-4108)
- Wei Wang (ORCID: https://orcid.org/0009-0003-7539-9394)
- Junhong Jiang
- Shenxuan Zhou
- Siqi Li (ORCID: https://orcid.org/0009-0008-2103-832X)
- Xiaobo Tao
- Anhui Ning
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Xian Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.117679
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Jiangsu Province
- National Key Research and Development Program of China