Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants
Shift work showed independent associations with knee osteoarthritis and self-reported osteoarthritis but not hip osteoarthritis, suggesting circadian rhythm dysfunction may play a role in knee osteoarthritis pathogenesis. Heavy manual work and prolonged non-sedentary work were associated with all outcomes, with stronger associations in knee osteoarthritis, possibly reflecting the knee's higher susceptibility to biomechanical stress. Further research is needed to explore workplace interventions for reducing these risks.
Authors
- Manfred Jung (ORCID: https://orcid.org/0000-0002-6361-7716)
- Qing‐Jun Meng (ORCID: https://orcid.org/0000-0002-9426-8336)
- Sophie K. Scott (ORCID: https://orcid.org/0000-0001-7510-6297)
- Jonathan H. Tobias (ORCID: https://orcid.org/0000-0002-7475-3932)
- Ahmar Hashmi (ORCID: https://orcid.org/0000-0002-1592-0606)
- BG Faber
- R A Beynon
Institutions
- Wellcome Centre for Cell-Matrix Research (GB)
- University of Manchester (GB)
- University of Bristol (GB)
- NIHR Oxford Musculoskeletal Biomedical Research Centre (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100565
- Citations
- 2
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Wellcome Trust
- Academy of Medical Sciences
- Versus Arthritis
- Medical Research Council