An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease
Our data show that eCIRP plays an important role in RIR-induced CKD. Treatment with C23 decreased renal inflammation, alleviated chronic renal injury and fibrosis, and inhibited ferroptosis in the RIR-induced CKD mice.
Authors
- Zhijian Hu (ORCID: https://orcid.org/0000-0001-5261-060X)
- Fangming Zhang
- Max Brenner (ORCID: https://orcid.org/0000-0002-8010-148X)
- Ping Wang (ORCID: https://orcid.org/0000-0002-1557-0394)
- Asha Jacob
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- TheraSource (United States) (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s10020-025-01071-2
- Citations
- 9
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 8.43
Funders
- National Institutes of Health