A distinct immunophenotype in children carrying the Blautia enterotype: The Generation R study
The Blautia enterotype showed features beneficial for human health. Enterotypes were associated with differences in memory B- and T-cell compartments. This study is unique in the detailed analysis of the B and T-cell compartment and the intestinal microbiome in a large generic pediatric cohort, enabling correction for child and maternal covariates. These outcomes could guide further studies about the impact of intestinal microbiome intervention, for instance through diet and microbiota metabolites such as short chain fatty acid production.
Authors
- Kyra N. Smit (ORCID: https://orcid.org/0009-0002-0238-2113)
- Paul A. Gill (ORCID: https://orcid.org/0000-0001-8579-8493)
- Sanne A. Beth
- Christina Großerichter-Wagener
- Robert Kraaij (ORCID: https://orcid.org/0000-0003-0416-999X)
- Henriëtte A. Moll (ORCID: https://orcid.org/0000-0001-9304-3322)
- Liesbeth Duijts (ORCID: https://orcid.org/0000-0001-6731-9452)
- Kirsten I. M. Looman (ORCID: https://orcid.org/0000-0002-1984-564X)
- Menno C. van Zelm (ORCID: https://orcid.org/0000-0003-4161-1919)
- Jessica C. Kiefte–de Jong (ORCID: https://orcid.org/0000-0002-8136-0918)
- Djawad Radjabzadeh
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- The Alfred Hospital (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Monash University (AU)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.clim.2025.110426
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81