Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation
These findings suggest that SR9009 may be a potential therapeutic approach for preventing weight gain and insulin resistance caused by circadian disruptions, likely through adipogenesis inhibition, though its effects on other metabolic pathways remain limited at low doses.
Authors
- Ming‐Yu Yang (ORCID: https://orcid.org/0000-0002-6841-5478)
- Hugo You‐Hsien Lin (ORCID: https://orcid.org/0000-0001-6888-4138)
- I‐Ya Chen
- Yi‐Ywan M. Chen (ORCID: https://orcid.org/0000-0002-8727-9811)
- Chao‐Hui Yang (ORCID: https://orcid.org/0000-0003-4055-1686)
- Ming-Luen Hu
Institutions
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Kaohsiung Municipal Ta-Tung Hospital (TW)
Publication Details
- Journal
- Biomedical Journal
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.bj.2025.100830
- Citations
- 5
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 4.57
Funders
- Chang Gung Memorial Hospital