Nivolumab combination therapies in patients with advanced gastric and gastroesophageal junction cancer: the phase II FRACTION gastric cancer study
While ORR did not meet prespecified expansion criteria in any treatment arm, the safety profile of the combinations was manageable. FRACTION-GC represents a novel adaptive protocol for testing multiple combination immunotherapies.
Authors
- Giuseppe Curigliano (ORCID: https://orcid.org/0000-0003-1781-2518)
- H. Park
- R. von Moos
- Ming Lei (ORCID: https://orcid.org/0000-0002-3962-6604)
- Veena Shankaran (ORCID: https://orcid.org/0000-0001-8136-6140)
- Do Hoon Lim (ORCID: https://orcid.org/0000-0002-5426-0604)
- S. Stein
- Aiwu Ruth He (ORCID: https://orcid.org/0000-0002-2104-0816)
- Harry H. Yoon (ORCID: https://orcid.org/0000-0001-6208-3487)
- Martina Di Bartolomeo (ORCID: https://orcid.org/0000-0003-4266-7607)
- E. Elimova
- Ravit Geva (ORCID: https://orcid.org/0000-0002-5380-4948)
- R. Fritsch
- Vincent K. Lam (ORCID: https://orcid.org/0000-0002-1319-2588)
- Geoffrey Y. Ku (ORCID: https://orcid.org/0000-0002-0448-1038)
- Adnan Nagrial (ORCID: https://orcid.org/0000-0003-0275-2479)
- Georg-Martin Haag
- Michael B. Sawyer (ORCID: https://orcid.org/0000-0002-2640-3620)
- C.S. Denlinger
- John M. Starr (ORCID: https://orcid.org/0000-0002-3059-7579)
- Talia Golan (ORCID: https://orcid.org/0000-0001-5939-7012)
- S.S. Kim
- T.J. George (ORCID: https://orcid.org/0000-0001-6653-6762)
- M. Gutierrez
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Amie Patel (ORCID: https://orcid.org/0000-0002-8433-6083)
- Danielle Greenawalt (ORCID: https://orcid.org/0000-0002-6297-0753)
- Tatsuo Aoyama
Institutions
- Fox Chase Cancer Center (US)
- City Of Hope National Medical Center (US)
- Hackensack University Medical Center (US)
- Johns Hopkins University (US)
- University of Alberta (CA)
- Georgetown University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Tel Aviv Sourasky Medical Center (IL)
- Georgetown University Medical Center (US)
- University of Florida Health (US)
- Jacksonville College (US)
- WinnMed (US)
- Princess Margaret Cancer Centre (CA)
- Yale University (US)
- Bristol-Myers Squibb (United States) (US)
- University of Colorado Cancer Center (US)
- Mayo Clinic in Florida (US)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Sidney Kimmel Comprehensive Cancer Center (US)
- UF Health Cancer Center
- Seattle University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.esmoop.2024.104107
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Bristol-Myers Squibb
- Agilent Technologies
- Celgene
- Ono Pharmaceutical