A community-based study for evaluation of Ayurvedic formulations in the management of Osteoarthritis Knee
Background: Osteoarthritis (OA) of the knee is a major public health concern that leads to pain, disability and decreased quality of life. A similar condition has been described in Ayurveda under the name Sandhigata Vata which is caused by vitiation of Vata in the body. Objectives: Evaluation of the effectiveness and tolerability of Yograj Guggulu, Ashwagandha Churna, and Narayana Taila in OA knee. Materials and methods: The study was a prospective, multi-center, non-controlled interventional, community-based study conducted in 10 centres in India. 493 participants of any gender aged between 40 to 65 years & diagnosed with OA knee as per the diagnostic criteria American College of Rheumatology (2012), were enrolled in the study considering selection criteria. Ayurvedic formulations, Yograj Guggulu & Ashwagandha Churna were administered orally along with the local application of Narayana Taila twice daily for 12 weeks. The assessment was carried out on 28th, 56th, 84th and 112th day for any changes in the outcome measures. Results: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score, the WOMAC sub-scores for pain, stiffness and difficulty in physical activity, the Visual Analogue Scale (VAS) score for pain and the disease-specific symptoms were significantly decreased throughout treatment and during follow-up without intervention. Conclusion: The study demonstrates that the Ayurvedic interventions are well tolerable and beneficial in reducing the symptoms of OA knee.
Authors
- Arunabh Tripathi (ORCID: https://orcid.org/0000-0001-7235-4236)
- Rakesh Kumar Rana (ORCID: https://orcid.org/0000-0002-3115-0701)
- Chris Antony (ORCID: https://orcid.org/0000-0002-5585-5570)
- Rahul Ghuse
- Kamble Pallavi Namdev
- Sunita Mata (ORCID: https://orcid.org/0000-0002-4878-7602)
- Narayanam Srikanth (ORCID: https://orcid.org/0000-0002-3976-4978)
- Parth Dave (ORCID: https://orcid.org/0000-0002-3399-4422)
- M. S. S. Mohan (ORCID: https://orcid.org/0009-0007-4999-0868)
- Deepa Makhija (ORCID: https://orcid.org/0000-0003-1607-5966)
- Aparna Manathottathil (ORCID: https://orcid.org/0009-0006-1551-0611)
- Rabinarayan Acharya (ORCID: https://orcid.org/0000-0003-4413-1937)
- Praveen Ks
- Abha Sharma (ORCID: https://orcid.org/0000-0001-9413-9131)
- Sahu Sk
- Sanjiv Kumar
- Neelam Singh (ORCID: https://orcid.org/0000-0002-3029-9053)
- S. Santhosh Kumar
- Amit Kumar (ORCID: https://orcid.org/0000-0001-9646-4982)
- Shyam Babu (ORCID: https://orcid.org/0000-0002-2892-9175)
- Bhogavalli Chandrasekhara Rao
- Alok Kumar Srivastava (ORCID: https://orcid.org/0000-0003-2989-8240)
- Gopesh Sharma (ORCID: https://orcid.org/0009-0005-7470-8313)
- Prashant Shinde
- Aaditya Shah
- Kavita Vyas
- Anukampa Singh
- Vandana Joshi (ORCID: https://orcid.org/0009-0008-2146-4839)
- Sai Prasad AJV
- Sekhar Namburi UR
- Bharati PL
- Reddy RG
- Summed Paikrao
Institutions
- Gujarat Ayurved University (IN)
- National Institute of Ayurveda (IN)
- Central Council for Research in Ayurvedic Science (IN)
- Government Ayurved College, Nanded (IN)
- Ministry of AYUSH (IN)
Publication Details
- Journal
- International Journal of Ayurvedic Medicine
- Published
- 2025-01-09
- DOI
- https://doi.org/10.47552/ijam.v15i4.5021
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00