Ultrasound pupillometry for the detection of a relative afferent pupillary defect (RAPD): Systematic evaluation in patients with optic neuritis and comparison with infrared video pupillometry
B-mode UP allows for objective detection and quantification of an RAPD with performance characteristics similar to IVP. RAPD assessment by UP may detect subclinical optic nerve damage in patients with MS. We propose a standardized protocol for RAPD detection by UP that can be used in routine clinical evaluation of patients with ON or other optic neuropathies.
Authors
- Charlotte Bereuter (ORCID: https://orcid.org/0009-0004-7172-8864)
- Stephan J. Schreiber (ORCID: https://orcid.org/0000-0003-0902-3447)
- Klemens Ruprecht (ORCID: https://orcid.org/0000-0003-1962-6014)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Lutz Harms
- Hanna Zimmermann (ORCID: https://orcid.org/0000-0002-0276-8051)
- Carolin Otto (ORCID: https://orcid.org/0000-0002-9768-5143)
- Jan Klonner (ORCID: https://orcid.org/0000-0002-8512-5624)
- Ulrike Grittner (ORCID: https://orcid.org/0000-0003-2595-0224)
- F Schmidt (ORCID: https://orcid.org/0009-0003-3041-9275)
- Franziska Siebald
Institutions
- Humboldt-Universität zu Berlin (DE)
- MSB Medical School Berlin (DE)
- Zimmer Biomet (Germany) (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1371/journal.pone.0315712
- Citations
- 2
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- Stiftung Charité
- Berlin Institute of Health