Chemotherapy-induced diminished murine ovarian reserve model and impact of low-dose chemotherapy on fertility
We successfully established a chemotherapy-induced DOR model using 12 mg/kg of Bu + 120 mg/kg of Cy, as evidenced by lower, but not completely depleted, follicle numbers and fewer retrieved embryos. Histologic study of ovarian tissue exposed to DOR-inducing chemotherapy revealed that surviving follicles were of the similar quality as tissue not exposed to chemotherapy.
Authors
- Jacques Donnez (ORCID: https://orcid.org/0000-0003-2528-206X)
- Jen‐Yu Wen
- Luciana Cacciottola (ORCID: https://orcid.org/0000-0001-6738-289X)
- Lara Houeis
- Marie‐Madeleine Dolmans (ORCID: https://orcid.org/0000-0002-6331-3026)
- Graziella van der Plancke (ORCID: https://orcid.org/0009-0008-2168-4006)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- European Society of Intensive Care Medicine (BE)
- Services déconcentrés d'appui à la recherche Val de Loire (FR)
- UCLouvain (BE)
Publication Details
- Journal
- F&S Science
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.xfss.2025.01.002
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds De La Recherche Scientifique - FNRS