Extraordinary Optical Transmission Biosensor for Rapid Hypoalbuminemia Diagnosis

Hypoalbuminemia, marked by low blood albumin levels, indicates various diseases and requires swift, accurate diagnostics. We developed a diagnostic kit with an Extraordinary Optical Transmission (EOT) biosensor for rapid, precise albumin measurement. Using nanohole arrays, the EOT sensor showed a 460 nm/RIU sensitivity and detected albumin as low as 10 mg/mL with a 0.8972 nm peak shift. It accurately classified 100 serum samples with over 98% accuracy. This kit provides a promising real-time, label-free diagnostic solution, particularly with advanced microfluidics and thin-film optics.