Bushen-Huoxue-Mingmu-Formula attenuates pressurization-induced retinal ganglion cell damage by reducing mitochondrial autophagy through the inhibition of the Pink1/Parkin pathway
MMF altered the expression of apoptosis- and autophagy-related proteins and possibly inhibited the Pink1/Parkin signaling pathway, which led to reduced pressurization-induced mitochondrial autophagy in RGCs. This preventive effect of MMF on RGCs can be potentially useful to preserve the viability of RGCs.
Authors
- Wubo Cheng
- Fen Yang (ORCID: https://orcid.org/0000-0001-8429-3733)
- Qianqian Mu (ORCID: https://orcid.org/0000-0002-2627-7898)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5273-3332)
- Dan Zhang (ORCID: https://orcid.org/0000-0003-1295-4795)
- Jia Gao (ORCID: https://orcid.org/0000-0001-6203-209X)
Institutions
- Yunnan University (CN)
- First People's Hospital of Chongqing (CN)
- Kunming Municipal Hospital of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Medicine
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1097/md.0000000000041257
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00