A Computationally Efficient Deep Learning-Based Surrogate Model of Prediabetes Progression

Early detection of prediabetes is crucial to preventing its progression to diabetes. Providing individuals with a personalized sense of their risk could improve prevention efforts. While complex mathematical models that simulate metabolic and inflammatory processes offer detailed and patient-specific insights, their computational cost usually makes them impractical for real-time prediction on mobile platforms.This work introduces a long short-term memory (LSTM) surrogate for the MT2D model, that simulates the main metabolic and inflammatory processes undergoing the transition to prediabetes. The model is developed using a dataset of 43 669 simulated subjects, each with lifestyle inputs and biomarker outputs over six months. Using 8 time series inputs, the surrogate predicts the dynamics of 11 key metabolic and inflammatory outputs, closely replicating the behaviour of the MT2D model.After training, the proposed LSTM model reduces computational time from an average of 8.4 hours to 0.1 seconds per simulation, making it suitable for mobile device deployment. The model achieves root mean squared errors on the order of 10<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−2</sup> on scaled data, and shows promise for prediabetes risk assessment by capturing trends in inflammatory biomarkers.This surrogate model can provide real-time and patient-specific insights into the metabolic health, potentially improving the understanding of prediabetes risk.