Computer-based Argumentation and PROMs Multi-objective Dynamic Management Decision Support System

The management of complex diseases and patient-centered personalized needs is increasingly demanding. While significant progress has been made in research on single-objective disease management and personalized medicine, there remains a lack of an integrated solution for coordinating multi-objective strategies and dynamically adjusting personalized approaches. This paper introduces a decision support system based on a computer-argumentation engine. This system builds an evidence-based knowledge repository from clinical and rehabilitation guidelines and constructs a patient-centered hierarchical conceptual framework for PROMs to evaluate goal realization benefits. It automates the recommendation of optimal treatments based on the reasoning of conflicts between objectives, incorporating patient preferences and priority of objectives to dynamically adjust daily health management decisions. Through a regular feedback mechanism via PROMs, the system iteratively updates and dynamically adjusts its argumentation based on user states and preferences. A prototype system has been designed and implemented, focusing on multi-objective management for breast cancer patients, to demonstrate the feasibility of this system.