OCD Diagnosis with Multiple Spatial Similarity-Aware Learning and Diffusion Structure-Aware Graph Convolutional Network

Obsessive-Compulsive Disorder (OCD) is a hereditary mental illness, and unaffected first-degree relative (UFDR) is also at high risk. This study constructed a framework based on traditional machine learning and deep learning methods to identify OCD and UFDR. Specifically, we propose Multiple Spatial Similarity-Aware Learning (MSSL) models to construct Brain Functional Connectivity Networks (BFCNs) and use Diffusion Structure-Aware Graph Convolutional Network (DSAGCN) for feature learning. Two regularization terms are added to the MSSL model, one is to limit the similarity of functional connectivity of adjacent brain regions, and the other is to constrain the similarity of signals in adjacent brain regions. In this strategy, redundant information can be removed while constructing the interrelationships of various brain regions, which can reflect the interrelationships between brain regions.The graph diffusion is introduced to the DSAGCN model, which can not only solve the edge noise problem caused by the graph structure constructed by the custom adjacency matrix but also enrich the node features by using the position information of the nodes on the reconstructed graph structure.This framework has been validated on our dataset collected from local hospitals, and the experimental results show that our proposed method outperforms the state-of-the-art.