Synthetic Organic Chemistry at Micro ScaleUsing Digital Microfluidics

In this minireview, digital microfluidics (DMF) is presented as an innovative option for automated organic synthesis at the microscale. Using DMF, valuable compounds, were successfully synthesized at the microliter scale. Additionally, organic reactions within the DMF devices were monitored using microcoil NMR and electrostatic spray ionization, allowing for kinetic analysis of rapid reactions. As DMF technology continues to advance and be integrated with synthetic organic chemistry, further miniaturization, automation, and acceleration of organic synthesis processes are anticipated.