GradeDiff-IM: an ensembles model-based grade classification of breast cancer

Cancer grade classification is a challenging task identified from the cell structure of healthy and abnormal tissues. The practitioners learns about the malignant cell through the grading and plans the treatment strategy accordingly. A major portion of researchers used DL models for grade classification. However, the behavior of DL models is hidden type, it is unknown which features contribute to the accuracy and how the features are chosen for grading. To address the issue the study proposes a Grade Differentiation Integrated Model (GradeDiff-IM) to classify the grades G1, G2, and G3. In GradeDiff-IM, different ML models, are used for grade classification from clinical and pathological reports. The biological-significant features with ranking technique prioritize influential features are used to identify grades G. Subsequently, histopathological images are used by DL models for grade classification and compared with ML models. Instead of employing a single ML model, the GradeDiff-IM model uses the stack-ensembled approach to improve the grade G classification performance. The maximum accuracy is attained by stacking G1-98.2, G2-97.6, and G3-97.5. The proposed study shows that the ML ensemble model is more accurate than the DL models. As a result, the proposed model achieved higher accuracy for G by implementing the stacking technique than the other state-of-the-art models.