Selective Synthesis of 2‐(Indol‐3‐Yl)Phenols via Iodine‐Catalyzed C3‐Arylation of Indoles with Cyclohexanones
Abstract An iodine‐catalyzed C3‐arylation of indoles with cyclohexanones to selectively synthesize 2‐(indol‐3‐yl)phenols has been described. Mechanism studies indicate that the oxygen atom in 2‐(indol‐3‐yl)phenols is originally from DMSO. This cascade involving dehydration condensation, selective oxygenation, dehydrogenation, and aromatization was achieved in one pot under transition‐metal‐free conditions.
Authors
- Shanping Chen
- Guo‐Jun Deng (ORCID: https://orcid.org/0000-0003-2759-0314)
- Yuxia Li (ORCID: https://orcid.org/0000-0003-1916-2707)
- Xinlin Zhou (ORCID: https://orcid.org/0000-0002-3530-0922)
- Qi Yin (ORCID: https://orcid.org/0000-0002-6382-5005)
- Chao Zhang (ORCID: https://orcid.org/0009-0008-2674-344X)
Institutions
- Xiangtan University (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1002/adsc.202401507
- Citations
- 6
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Henan Normal University
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Hunan Province