Dnmt3a-mediated DNA Methylation Regulates P. gingivalis-suppressed Cementoblast Mineralization Partially Via Mitochondria-dependent Apoptosis Pathway
P. gingivalis blocks DNA methylation by silencing Dnmt3a in cementoblasts, thereby inducing mitochondrial-dependent apoptosis and, ultimately, impaired cementogenesis.
Authors
- Huiyi Wang (ORCID: https://orcid.org/0000-0001-7519-7766)
- Qiudong Yang
- Zhengkun Yang (ORCID: https://orcid.org/0000-0002-6726-5914)
- Xin Huang (ORCID: https://orcid.org/0000-0002-5625-0338)
- Zhengguo Cao (ORCID: https://orcid.org/0000-0002-4261-9034)
- Yang Liu (ORCID: https://orcid.org/0000-0002-4989-2404)
- Chuan Wang (ORCID: https://orcid.org/0000-0001-5165-8273)
- Jiahui Sun
- Xiaoxuan Wang (ORCID: https://orcid.org/0000-0001-6558-4439)
- Li Ma (ORCID: https://orcid.org/0000-0001-7688-3397)
- Junhong Xiao (ORCID: https://orcid.org/0009-0002-3357-2702)
- Hantao Huang
- Yan Peng
- Heyu Liu
Institutions
- Wuhan University (CN)
Publication Details
- Journal
- Inflammation
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1007/s10753-024-02235-8
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Wuhan University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities