Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage
SETD7 plays a critical role in the pathogenesis of OA by modulating chondrocyte survival, apoptosis, inflammation, and autophagy. The interaction between YTHDF2 and SETD7 exacerbates chondrocyte injury under inflammatory conditions, highlighting potential therapeutic targets for OA treatment. The YTHDF2/SETD7 axis offers a novel insight into the molecular mechanisms governing cartilage degeneration in OA.
Authors
- Lexiang Li (ORCID: https://orcid.org/0000-0001-8028-2148)
- Jun Zhu (ORCID: https://orcid.org/0000-0002-0859-3483)
- Yaguang Han (ORCID: https://orcid.org/0000-0003-3861-3358)
- Bo Wang (ORCID: https://orcid.org/0000-0002-0666-8509)
- Haobo Li (ORCID: https://orcid.org/0000-0002-1234-4412)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7769-7377)
- Yi Chen (ORCID: https://orcid.org/0000-0002-3054-0839)
Institutions
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/jgm.70005
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34