Prioritizing attributes of approaches to analyzing patient-centered outcomes that are truncated due to death in critical care clinical trials: a Delphi study
We found that methods used to account for truncation due to death in the treatment effect definition and statistical approach in critical care trials should meet at least four defined criteria: accuracy, interpretability, clinical relevance, and patient-centeredness. Future work is needed to derive objective criteria to quantify how well existing estimands and analytic approaches encompass these attributes.
Authors
- Catherine L. Auriemma (ORCID: https://orcid.org/0000-0003-4803-0375)
- Brennan C Kahan (ORCID: https://orcid.org/0000-0001-9957-0844)
- Fan Li (ORCID: https://orcid.org/0000-0002-8024-8326)
- Michael O. Harhay (ORCID: https://orcid.org/0000-0002-0553-674X)
- Melanie Bahti (ORCID: https://orcid.org/0009-0008-6998-5289)
Institutions
- Yale University (US)
- MRC Clinical Trials Unit at UCL (GB)
- University College London (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Trials
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s13063-024-08673-x
- Citations
- 1
- Primary Topic
- Delphi Technique in Research
- Type
- article
- Field-Weighted Citation Impact
- 4.20
Funders
- Patient-Centered Outcomes Research Institute
- National Institutes of Health
- Medical Research Council
- National Heart, Lung, and Blood Institute
- NHLBI Division of Intramural Research