A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis
Topical administration of a SOCS1 peptide mimic is safe to the equine eye and reduces ERU associated cytokines IL-10 and TNFα serving as potential biomarkers of drug efficacy in a future clinical trial.
Authors
- Daniel J. Gibson (ORCID: https://orcid.org/0000-0003-0379-0100)
- Lauren Stewart Stafford (ORCID: https://orcid.org/0000-0003-1518-0852)
- Valeria Vicuna
- Jatin Sharma (ORCID: https://orcid.org/0000-0002-4755-9253)
- Caryn E. Plummer (ORCID: https://orcid.org/0000-0003-0917-4130)
- W. Clay Smith (ORCID: https://orcid.org/0000-0002-6644-0231)
- Joseph Larkin (ORCID: https://orcid.org/0000-0003-2066-6814)
- S Diakité
Institutions
- University of Alabama (US)
- University of Florida (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1513157
- Citations
- 1
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Grayson-Jockey Club Research Foundation
- International Centre for Bamboo and Rattan