Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia
These data define two new BPH immune subpopulations, TREM2<sup>high</sup> and MARCO<sup>high</sup> macrophages, and suggest that lipid-rich macrophages may exacerbate lower urinary tract symptoms in patients with large prostates. Further investigation is needed to evaluate the therapeutic benefit of targeting these cells in BPH.
Authors
- Renee E. Vickman (ORCID: https://orcid.org/0000-0002-5614-9221)
- Simon W. Hayward (ORCID: https://orcid.org/0000-0002-6059-6550)
- Meaghan M. Broman (ORCID: https://orcid.org/0000-0001-5473-1616)
- Andrew M. Higgins (ORCID: https://orcid.org/0000-0002-0253-0692)
- Nadia A. Lanman (ORCID: https://orcid.org/0000-0002-1819-7070)
- Alexander P. Glaser (ORCID: https://orcid.org/0000-0003-1781-9023)
- Yana Filipovich
- Harish Kothandaraman (ORCID: https://orcid.org/0000-0002-0759-4601)
- Susan E. Crawford (ORCID: https://orcid.org/0000-0003-3890-5000)
- Pooja Talaty
- Timothy L. Ratliff (ORCID: https://orcid.org/0000-0003-4221-5416)
- Gregory M. Cresswell (ORCID: https://orcid.org/0000-0003-0616-0366)
- Omar E. Franco (ORCID: https://orcid.org/0000-0002-0673-9506)
- Svetlana Brumer
- Era Meco
- Andree K. Kolliegbo
- Malgorzata Antoniak
- Brian T. Helfand (ORCID: https://orcid.org/0000-0002-7707-3318)
- Philip Fitchev
- Chi-Hsiung Wang
Institutions
- NorthShore University HealthSystem (US)
- Purdue University West Lafayette (US)
- Louisiana State University in Shreveport (US)
- University of Chicago (US)
- Purdue University Institute for Cancer Research
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1494476
- Citations
- 7
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 7.84
Funders
- Walther Cancer Foundation
- Purdue University
- NorthShore University HealthSystem
- National Institutes of Health
- Melvin and Bren Simon Cancer Center, Indiana University
- National Institute of Diabetes and Digestive and Kidney Diseases