Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling
The <i>in vivo</i> relative recovery was determined to be 10.9% ± 3.7%. The antifungal tissue penetration was 0.77 and 0.71 for the healthy and infected animals, respectively. The structural PK model with two compartments and linear elimination describes the concentration versus time profile of AmB simultaneously in the plasma and tissue. Infection by <i>C. albicans</i> does not interfere with AmB kidney penetration. AmB protein binding is demonstrated to be nonlinear and dependent on the AmB concentration in the plasma of healthy and infected animals.
Authors
- Laiz Campos Pereira (ORCID: https://orcid.org/0000-0002-0490-9807)
- Matheus Antônio da Hora Borges
- Luisa Oliveira Santos (ORCID: https://orcid.org/0000-0002-8851-3438)
- Cristiane Flora Villarreal (ORCID: https://orcid.org/0000-0002-0113-7864)
- Francine Johansson Azeredo (ORCID: https://orcid.org/0000-0003-3625-0186)
- Carolina Magalhães Brandão (ORCID: https://orcid.org/0000-0002-2119-7135)
- Valdeene Vieira Santos (ORCID: https://orcid.org/0000-0003-2564-5254)
- Jackeline Marley Santos de Araújo (ORCID: https://orcid.org/0000-0001-7549-5704)
Institutions
- Universidade Federal da Bahia (BR)
- University of Florida (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fphar.2024.1515462
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Universidade Federal do Rio Grande do Norte