Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo
IGFBP5 eases inflammation by interacting with ANXA2, an activator of NF-κB; as an antagonist of IGF1/IGF1R, IGFBP5 may disrupt immune homeostasis <i>in vivo</i>, due to impairment of the latter's anti-inflammatory functions; excessive IGFBP from adipocytes would be a pathogenic factor in certain diseases.
Authors
- Kai Guo (ORCID: https://orcid.org/0000-0002-4651-781X)
- Yijin Wu (ORCID: https://orcid.org/0000-0002-6169-9084)
- Yan Jing Fan (ORCID: https://orcid.org/0000-0002-0452-902X)
- Cong‐Lan Ji (ORCID: https://orcid.org/0000-0002-9901-1070)
- Opeyemi Joshua Olatunji (ORCID: https://orcid.org/0000-0002-6800-4919)
- Jian Zuo (ORCID: https://orcid.org/0000-0003-4940-9408)
- Xiaqing Zhou (ORCID: https://orcid.org/0009-0009-7562-8832)
- Abulizi Abulaiti
Institutions
- Wannan Medical College (CN)
- Sichuan University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Xinjiang Uygur Autonomous Region Uygur Medicine Hospital (CN)
- Université Mohammed VI Polytechnique (MA)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1539317
- Citations
- 7
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province