Cytokine-induced Neurogenesis for the Prevention and Treatment of Alzheimer’s Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease for which no curative treatment has been established.We administered cytokine-induced neurogenesis treatment combined with a ketogenic and elimination diet to a 66-year-old male AD patient carrying APOE 4/4 alleles to regenerate residual neuronal stem cells.The treatment resulted in the successful regeneration of the atrophied hippocampus, which was associated with improved cognitive function and the resolution of electrophysiological abnormalities.We analyzed food allergies to identify the modifiers that influence AD progression.A food allergy analysis panel revealed that the specific IgG antibodies for casein, cow milk, and whey were positive, whereas the specific IgG antibody for gluten was negative; these allergies were improved by the ketogenic and elimination diet and associated with improved cognition.