Ferric Chloride and DABCO as a Versatile and Effective Catalytic System for Synthesis Thiazolidinedione Phamacophore

A mild and efficient procedure for the synthesis of synthetic approach for creating 2, 4-thiazolidinedione derivatives through the Knoevenagel condensation reaction, substituted benzaldehyde with 2,4-thiazolidinedione in ethanol catalysed by Ferric chloride and DABCO as a versatile and effective catalyst. These 2, 4-thiazolidinedione derivatives are significant due to their diverse biological activities’ significant advantages, such as cost-effectiveness, non-toxicity, and operational simplicity and high yield.