Identification of hub genes and immune-related pathways in acute myeloid leukemia: insights from bioinformatics and experimental validation
We conclude that <i>CFD</i> gene uses IL-2 as a mediator to promote the disease progression of AML by promoting the CD27 on CD24+CD27+B cells, JAK-STAT, and PI3K-Akt pathways.
Authors
- Wenzhe Yang (ORCID: https://orcid.org/0009-0008-4085-0997)
- Zhaoqing Cui
- Mingliang Shan
- Shiguo Liu (ORCID: https://orcid.org/0000-0001-6474-4082)
- Li Xu
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Qingdao University (CN)
- Liaocheng People's Hospital (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1511824
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54