CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment
Our findings demonstrate that elevated CA19-9 levels during immunotherapy are associated with poor survival outcomes in HCC patients. These findings highlight the crucial role of CA19-9 in shaping the tumor immune environment, particularly through its effect on macrophage polarization, and suggest that targeting CA19-9 may improve immunotherapy outcomes.
Authors
- Yunying Yang (ORCID: https://orcid.org/0000-0002-5176-038X)
- Hui Pang
- Tingting Du (ORCID: https://orcid.org/0000-0002-1350-6778)
- Jialin Zou
- Shutong Wang (ORCID: https://orcid.org/0000-0002-4332-3075)
- Wenquan Zhuang (ORCID: https://orcid.org/0000-0002-6384-2489)
- Honghui Xie
- Guangyan Wei (ORCID: https://orcid.org/0000-0002-3137-1483)
Institutions
- Sun Yat-sen University (CN)
- People’s Hospital of Wenshan Prefecture (CN)
- Longgang Central Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fonc.2024.1528138
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China