ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment—a study based on mouse models and clinical practice
This study may provide new insights into targeting the regulation of TME and offer theoretical and practical support for the clinical application of CHA. The results demonstrated the potential of CHA in improving the immune microenvironment and antitumor effects, which could have implications for future glioma treatment strategies.
Authors
- Ren-Kui Bai
- Feng Chen (ORCID: https://orcid.org/0000-0003-4819-2518)
- Jian‐Dong Jiang
- Yuxiang Fan (ORCID: https://orcid.org/0000-0001-9329-3866)
- Jiachen Wang (ORCID: https://orcid.org/0000-0002-5070-7309)
- Zehao Cai
- Mengqian Huang (ORCID: https://orcid.org/0000-0002-5738-2674)
- Yuxiao Chen (ORCID: https://orcid.org/0000-0001-7597-246X)
- Can Wang (ORCID: https://orcid.org/0000-0002-2890-0057)
- Wenbin Li (ORCID: https://orcid.org/0000-0003-3096-4831)
- Shenglan Li (ORCID: https://orcid.org/0000-0002-3117-2601)
- Jinyi Chen (ORCID: https://orcid.org/0000-0001-8765-6878)
- Yumeng Yu
- Yanjie Lan (ORCID: https://orcid.org/0009-0009-8502-4813)
- Zhuang Kang (ORCID: https://orcid.org/0009-0006-6962-0357)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1494806
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China