Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells

The present work characterizes one of the earliest sequences in the establishment of pre-AC and suggests that subsets of EE-derived tubular membranes may serve as the earliest biomarkers in pre-AC biogenesis. Our study also indicates that the pre-AC biogenesis is complex and likely involves multiple parallel processes, of which Rab10-PD expansion is one. Our experiments, particularly our silencing experiments, show that Rab10 and EHBP-1 do not play a significant role in the later stages of inner pre-AC biogenesis or in the expansion of downstream tubular domains. A more comprehensive understanding of the tubular domain expansion remains to be established.

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Publication Details

Journal
Frontiers in Cell and Developmental Biology
Published
2025-01-10
DOI
https://doi.org/10.3389/fcell.2024.1517236
Citations
2
Primary Topic
Cytomegalovirus and herpesvirus research
Type
article
Field-Weighted Citation Impact
2.71

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article

Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells

Ljerka Karleuša, Antonija Jurak Begonja, Hana Mahmutefendić Lučin, Matej Skočaj et al.
2 citations
Frontiers in Cell and Developmental Biology
Cytomegalovirus and herpesvirus research
2.71
article

Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells

Ljerka Karleuša, Antonija Jurak Begonja, Hana Mahmutefendić Lučin, Matej Skočaj, Martina Deželjin, Gordana Blagojević Zagorac, Marina Marcelić, Ivona Viduka, Pero Lučin, Berislav Lisnić, Igor Štimac, Alen Omerović, B. Radic
article en
2 citations

Abstract

The present work characterizes one of the earliest sequences in the establishment of pre-AC and suggests that subsets of EE-derived tubular membranes may serve as the earliest biomarkers in pre-AC biogenesis. Our study also indicates that the pre-AC biogenesis is complex and likely involves multiple parallel processes, of which Rab10-PD expansion is one. Our experiments, particularly our silencing experiments, show that Rab10 and EHBP-1 do not play a significant role in the later stages of inner pre-AC biogenesis or in the expansion of downstream tubular domains. A more comprehensive understanding of the tubular domain expansion remains to be established.

Frontiers in Cell and Developmental BiologyVol. 12
University of Ljubljana (SI), University of Rijeka (HR), Medizinische Hochschule Hannover (DE), University North (HR), Ruđer Bošković Institute (HR)
Hrvatska Zaklada za Znanost
Openalex Percentile: Top 13%
Cytomegalovirus and herpesvirus research
2.71
DOIOpen Access PDFOpenAlex
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Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells — Ljerka Karleuša, Antonija Jurak Begonja, et al. · Frontiers in Cell and Developmental Biology (2025) | TGRS Research Map | TGRS