Evaluation of skin irritation and skin sensitization potential of Venusia CeraPlus cream using human repeat insult patch test

Objectives: This study evaluated the safety of Venusia CeraPlus Moisturizing Cream using the human repeat insult patch test (HRIPT). Materials and Methods: A single-center, non-randomized, double-blinded, observational study was conducted from February 12 to March 27, 2024. 211 participants (aged 18–65, Fitzpatrick skin types III–V) completed the study. The HRIPT protocol included induction, rest, and challenge phases. Skin reactions were assessed using the Draize scale during induction and the International Contact Dermatitis Research Group scale during the challenge phase. Results: The study demonstrated favorable results for Venusia CeraPlus moisturizing cream. During the induction phase, the product showed a mean cumulative irritation score of 0.37, which was well below the non-irritant threshold of 2. In the challenge phase, no participants exhibited strong positive reactions (++) at any time point. No adverse events were reported by any of the participants. Conclusion: Venusia CeraPlus moisturizing cream demonstrated non-irritant properties after nine repeat applications and was found to be hypoallergenic in the study population.