Loss of Parp7 increases type I interferon signalling and reduces pancreatic tumour growth by enhancing immune cell infiltration
Our data show that loss of Parp7 reduces PDAC tumour growth by increasing the infiltration of immune cells and enhancing anti-tumour immunity. These findings provide support to pursue PARP7 as a therapeutic target for cancer treatment.
Authors
- Toivo Maimets (ORCID: https://orcid.org/0000-0001-6461-3365)
- Ninni Elise Olafsen (ORCID: https://orcid.org/0000-0002-4494-3858)
- Indrek Teino (ORCID: https://orcid.org/0000-0002-2381-4715)
- Siddhartha Das (ORCID: https://orcid.org/0000-0002-4471-1600)
- Hani Choksi
- Vinicius Kannen (ORCID: https://orcid.org/0000-0001-6290-8063)
- Jason Matthews (ORCID: https://orcid.org/0000-0002-9815-8636)
- Paola Cappello (ORCID: https://orcid.org/0000-0002-5321-7794)
- Paolo Giuliana (ORCID: https://orcid.org/0000-0003-0424-1138)
- Žilvinas Dambrauskas (ORCID: https://orcid.org/0000-0003-2173-1294)
- Antanas Gulbinas (ORCID: https://orcid.org/0000-0002-6683-1339)
- Samaneh Shabani Åhrling
- Landon J. Edgar (ORCID: https://orcid.org/0000-0001-6555-7609)
- Kristaps Jaudzems (ORCID: https://orcid.org/0000-0003-3922-2447)
- Marit Rasmussen (ORCID: https://orcid.org/0000-0003-0763-6725)
- Linnea A. M. Erlingsson
- Denis M. Grant
- Fauzia N. Izzati
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Oslo (NO)
- University of Toronto (CA)
- Latvijas Organiskās Sintēzes Institūts (LV)
- University of Turin (IT)
- University of Tartu (EE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1513595
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Associazione Italiana per la Ricerca sul Cancro
- Norges Forskningsråd
- Canadian Institutes of Health Research
- Canadian Glycomics Network